Fibric Acid Derivatives are drugs under the brand names Lopid (gemfibrozil) or Atromid-S (clofibrate) that enhance the body's ability to break down triglyceride rich lipid particles, and, as a result, effectively reduce triglyceride levels.UsesIn patients with very high triglyceride levels, the reduction of triglycerides by these drugs can decrease the risk of inflammation of the pancreas, a very dangerous condition. In patients at risk for heart disease, these drugs have been shown to reduce the rate of development of heart attacks and coronary deaths.
Effects on Blood Lipids
DosageConsult your CCT physician about the appropriate times of day and quantities of this drug. It is generally recommended to be taken slightly before or with meals.
These medications, packaged under the names Crestor, Mevacor, Pravachol, Zocor, Lipitor or Lescol, block the production of cholesterol within cells, causing the cells to increase specific receptors on their surface that will take up LDL cholesterol particles from the blood. This effect is especially prominent in the liver, which is the organ that largely controls cholesterol in the body. As the number of LDL receptors increases, the levels of total and LDL cholesterol in the blood will go down.
Effects on Blood Lipids
Taken with other medication, such as cholestyramine resin, has led to the reversal of coronary artery blockage in a substantial number of patients.
Drug InteractionConsult with your CCT physician about taking HMG-CoA Reductase Inhibitors if you are taking cyclosporine, gemfibrozil, niacin, erythromycin or any other prescription medication, particularly those prescribed for cholesterol/lipid lowering purposes.DosageTimes and amounts vary by patient; consult your physician or pharmacist. Typically, the drug is taken in the evening with food for better absorption.
Also known as Vitamin B3, niacin is available in many generic and brand name formulations for use in lipid lowering applications.UsesDoses of niacin (1000 milligrams) significantly above the recommended daily requirement of 20 milligrams a day will decrease the liver's production of lipoprotein particles and can enhance the breakdown of these particles. A large study has shown that niacin may increase life expectancy in patients with coronary heart disease. Reversal of coronary artery disease has been achieved with the combination of niacin and bile acid binding resins. Effects on Blood Lipids
DosageNiacin should always be taken with some food in the stomach, and the same brand should be continually used to prevent flushing or diminished effect. Do not use niacinamide or nicotinamide as substitutes, as they have no lipid-lowering effects.Do not use time-released niacin. Work with your physician to schedule the proper dosing schedule of niacin, which is typically taken several times a day for lipid-lowering purposes. Your CCT doctor will provide a specific schedule to you. This schedule will also tell you when you are to return for lab work.
Nitroglycerin sublingual (under the tongue) or spray is a commonly prescribed medication that relaxes blood vessels, widens coronary arteries and increases the supply of blood and oxygen to the heart. Uses It is used to relieve angina (chest pain), relieve smooth muscle pain that is not heart-related and may be used to prevent pain before strenuous exercise. To be taken when there is discomfort in the jaw, neck, shoulders, arm/hand; when there is chest pain/pressure; or for cold sweats, nausea or shortness of breath. Treatment Before treating with nitroglycerin, sit or lie down at the first indication of chest pain. Often, the pain will disappear with rest. If after five minutes the pain persists: Tablets
Adverse Reactions Headache, dizziness, lowered blood pressure, fast heart rate and/or hot, flush feeling. Generally, these reactions last only a few minutes. Storage