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For more information about these studies, please call 469.800.7400

Interventional Research

Study Name: CoreValve®

Study Description: According to research, without effective treatment, as many as 50 percent of aortic stenosis patients with sever symptoms die within one year.  Baylor Hamilton Heart and Vascular Hospital is currently enrolling patients in the trial.  If you feel your patient is at high risk for open heart surgery with aortic stenosis, Baylor will be happy to evaluate if they are eligible for the trial.  CoreValve® will be an option for patients who previously had no other options.

Location: Baylor Jack and Jane Hamilton Heart and Vascular Hospital is one of a select group of clinical sites now participating in a new U.S. clinical trial to evaluate treatment for a common heart disease, severe aortic stenosis.  The clinical trial, locally led by primary investigator Robert Stoler, MD, FACC, FSCAI, Co-Medical Director of Cardiology and Medical Director of the Catheterization Lab, is evaluating the Medtronic CoreValve® System as a non-surgical, minimally invasive treatment option for patients with severe aortic stenosis who are at high risk, or are eligible, for open-heart surgery.

Study Name: Endeavor IV

Study Description: To test the safety and effectiveness of the Endeavor stent.

Study Name: Syntax

Study Description: To show non-inferior PCI outcomes at 12 months compared with CABG treatment in patients requiring vascularization for 3VD or left main disease.

Study Name: Perseus

Study Description: To evaluate the next generation Taxus (Taxus Element) compared to Taxus Express.

Study Name: Elite

Study Description: To show a non-inferior safety and efficacy between the Cypher Elite and Cypher Bx Velocity.

Study Name: Gravitas

Study Description: To determine whether tailored anti-platelet therapy using the Accumetrics Verify-Now P2Y12 assay reduces MACE after drug-eluting stent implantation.

Study Name: ABCD

Study Description: Assess differences in post-discharge satisfaction among patients randomized to receive early discharge following PCI compared with their counterparts who are randomized to an overnight hospital stay in low-risk PCI patients.

Study Name: XIENCE

Study Description: A post-market registry.

Study Name: Resolute

Study Description: To determine safety and efficacy of the Resolute Zotarolimus-eluting stent.

Study Name: Platinum

Study Description: To determine safety and efficacy of the Promus Element stent.

Study Name: Coral

Study Description: To answer the question: What is the best treatment for patients who have high blood pressure and renal artery stenosis.

Study Name: Educate

Study Description: Dual-Antiplatelet Registry

Study Name: Rewards-TLX

Study Description: A retrospective study looking at Taxus Liberte' vs. XIENCE.

Study Name: Boss Trial

Study Description: Evaluation of sodium bicarbonate to reduce the incidence of Contrast-Induced Nephropathy in Patients with Chronic Kidney Disease who are undergoing Angiography.

Study Name: CoreValve

Study Description: The CoreValve transcatheter aortic valve system is designed to enable replacement of a diseased aortic valve without open-heart surgery and without surgical removal of the diseased valve.

Study Name: Excel

Study Description: To show non-inferior PCI outcomes at 12 months compared with CABG treatment in patients requiring vascularization for 3VD or left main disease.

Study Name: Translate-ACS

Study Description: A longitudinal observational acute coronary syndrome (ACS) study.

Electrophysiology Research

Study Name: aCRT

Study Description: To demonstrate non-inferiority of aCRT algorithm compared to echo-optimized BiV CRT.

Study Name: CABANA

Study Description: To compare catheter ablation vs. anti-arrhythmic drug therapy for atrial fibrillation.

 Study Name: Crystal AF

Study Description: To compare continuous monitoring by implantable loop recorder to standard of care medical treatment in subjects after cryptogenic stroke.

Study Name: Duo Flair

Study Description: To test safety and efficacy of Cool Path Ablation system for atrial flutter.

Study Name: IRASE

Study Description: To test safety and efficacy of Cool Path Ablation system for paroxysmal atrial fibrillation.

 Study Name: 4195 Extraction

Study Description: Evaluate safety of 4195 lead removal compared to removal of other Medtronic LV leads.

Study Name: SLS

Study Description: To evaluate long-term performance of specific (4195, 4196, etc.) leads and generators. 

Study Name: 4196

Study Description: New LV lead for Biv pacing designed to provide a non-invasive option to pace the LV lead from a second location post-implant.

Study Name: AVERT AF

Study Description: Determine if combination of AVJ ablation followed by BiV pacing improves functional status and exercise capacity compared to rate control meds in patients with chronic AF and depressed EF (single chamber ICD + meds vs. AVJ ablation + CRTD).

 Study Name: MASH

Study Description: Evaluate ability of Pressure Sensor Defibrillation Lead to meet implant criteria for sensing, pacing, defibrillation and pressure sensing efficacy.

Study Name: Optimize RV

Study Description: Comparing safety and effectiveness RV lead placement in septum vs. apex.

 Study Name: REASSURE

Study Description: Determine safety and efficacy of PPM that incorporates capability to treat atrial arrhythmias ATP and sudden cardiac death.

Study Name: Reduce HF

Study Description: Evaluate safety and effectiveness of CHRONICLE ICD system which combines single, dual or BiV device with ability to record and report intracardiac pressure to assess impact of evaluating heart failure related events.

Study Name: RESET

Study Description: Assess effect of rate-adaptive pacing in patients with diastolic heart failure and chronotropic incompetence by evaluating functional capacity and quality-or-life changes.

 Study Name: RIGHT

Study Description: Post-market comparing incidence of VT/VF therapies delivered for SVT episodes in Guidant vs. Medtronic devices.

Study Name: 4195 Chronic Performance

Study Description: To evaluate long-term performance of 4195 lead LV lead.


Study Description: VEST: Test hypothesis that non-invasive wearable defibrillator vest will reduce overall mortality in 60 days post-MI in patients with EF<35%

  • Lif​eVest = Optimal post MI/CHF Treatment vs. Optimal Post-MI Treatment Online

Predicts: Develop risk stratification tool that predicts occurrence of face ventricular arrhythmias that would result in ICD shocks during 5 years after MI and I.D.'s which patients which benefit from ICD vs. REVEAL monitor.

  • ICD in participants who still have LVEF <35% at end of VEST
  • REVEAL monitor in those with LVEF>35% at end of VEST