Fibric Acid Derivatives

Definition

Fibric Acid Derivatives are drugs under the brand names Lopid (gemflbrozil) or Atromid-S (clofibrate) that enhance the body's ability to break down triglyceriderich lipid particles, and, as a result, effectively reduce triglyceride levels.

Uses
In patients with very high triglyceride levels, the reduction of triglycerides by these drugs can decrease the risk of inflammation of the pancreas, a very dangerous condition. In patients at risk for heart disease, these drugs have been shown to reduce the rate of development of heart attacks and coronary deaths.

Effects On Blood Lipids

Triglycerides are reduced 25 to 50 percent
HDL Cholesterol is increased 10 to 20 percent
Total cholesterol and LDL cholesterol are usually reduced 10 to 15 percent

Adverse Reactions
Stomach discomfort and nausea
Skin rash
Abnormal liver enzyme tests
Muscle pains
Diarrhea
Makes the bile thicker and increases risk of gall bladder problems
Can potentiate the blood-thinning effect of warfarin (Coumadin)

Dosage
Consult your CCT physician about the appropriate times of day and quantities of this drug. Usually recommended to be taken slightly before or with meals.

Source: Lipid Metabolism and Atherosclerosis Clinic Baylor College of Medicine/The Methodist Hospital 3/94





	Definition Fibric Acid Derivatives are drugs under the brand names Lopid (gemflbrozil) or Atromid-S (clofibrate) that enhance the body's ability to break down triglyceriderich lipid particles, and, as a result, effectively reduce triglyceride levels. Uses In patients with very high triglyceride levels, the reduction of triglycerides by these drugs can decrease the risk of inflammation of the pancreas, a very dangerous condition. In patients at risk for heart disease, these drugs have been shown to reduce the rate of development of heart attacks and coronary deaths. Effects On Blood Lipids Triglycerides are reduced 25 to 50 percent HDL Cholesterol is increased 10 to 20 percent Total cholesterol and LDL cholesterol are usually reduced 10 to 15 percent Adverse Reactions Stomach discomfort and nausea Skin rash Abnormal liver enzyme tests Muscle pains Diarrhea Makes the bile thicker and increases risk of gall bladder problems Can potentiate the blood-thinning effect of warfarin (Coumadin) Dosage Consult your CCT physician about the appropriate times of day and quantities of this drug. Usually recommended to be taken slightly before or with meals. Source: Lipid Metabolism and Atherosclerosis Clinic Baylor College of Medicine/The Methodist Hospital 3/94 The information contained in this web site is presented for information purposes only, and is not intended to substitute in any way a consultation with a physician or competent healthcare professional for medical diagnosis and/or treatment.